/* MutationRx — clinical-science design system.
   Calm cool "paper", editorial serif display, a single teal signature, and a colorblind-checked
   four-bucket data palette held apart from the brand. Data hues are load-bearing; chrome is quiet. */
:root{
  --serif:"Iowan Old Style","Palatino Linotype",Palatino,"Book Antiqua",Georgia,serif;
  --sans:system-ui,-apple-system,"Segoe UI",Roboto,sans-serif;
  --mono:ui-monospace,"SF Mono",Menlo,Consolas,monospace;

  --paper:#eef1f2; --surface:#ffffff; --surface-2:#f7f9fa; --inset:#f2f5f6;
  --ink:#0f1519; --ink-2:#47535d; --muted:#8994a0; --faint:#aab3bc;
  --line:#e4e9ec; --hair:#eceff1; --border:rgba(15,21,25,.09);
  --brand:#0e8f96; --brand-ink:#0a6a70; --brand-2:#12a8a3; --brand-tint:rgba(14,143,150,.08);
  --shadow-sm:0 1px 2px rgba(15,21,25,.05);
  --shadow:0 1px 2px rgba(15,21,25,.04),0 8px 24px -6px rgba(15,21,25,.10);
  --shadow-lg:0 2px 4px rgba(15,21,25,.05),0 20px 46px -10px rgba(15,21,25,.16);

  --c-weakened:#d03b3b; --c-robust:#0ca30c; --c-improved:#2a6fd6; --c-nonbinder:#96a0aa;
  --tint-w:rgba(208,59,59,.055); --tint-r:rgba(12,163,12,.06); --tint-i:rgba(42,111,214,.06); --tint-n:rgba(150,160,170,.05);
  --amber:#c98a12; --amber-tint:rgba(201,138,18,.09);
  --radius:16px; --radius-sm:11px;
}
@media (prefers-color-scheme:dark){
  :root{
    --paper:#0a0e11; --surface:#141a1f; --surface-2:#10161a; --inset:#0e141880; --ink:#eef3f5;
    --ink-2:#aeb9c2; --muted:#7a8792; --faint:#5c6771; --line:#232c33; --hair:#1c242a;
    --border:rgba(255,255,255,.08);
    --brand:#2ec4c8; --brand-ink:#6bd8da; --brand-2:#39d0cf; --brand-tint:rgba(46,196,200,.11);
    --shadow-sm:0 1px 2px rgba(0,0,0,.3);
    --shadow:0 1px 2px rgba(0,0,0,.3),0 10px 30px -8px rgba(0,0,0,.5);
    --shadow-lg:0 2px 6px rgba(0,0,0,.4),0 24px 56px -12px rgba(0,0,0,.6);
    --c-weakened:#e66b6b; --c-robust:#25b825; --c-improved:#4a90e8; --c-nonbinder:#8a95a0;
    --tint-w:rgba(230,107,107,.10); --tint-r:rgba(37,184,37,.10); --tint-i:rgba(74,144,232,.11); --tint-n:rgba(138,149,160,.07);
    --amber:#e0a531; --amber-tint:rgba(224,165,49,.13);
  }
}
:root[data-theme=light]{ color-scheme:light;
  --paper:#eef1f2; --surface:#ffffff; --surface-2:#f7f9fa; --inset:#f2f5f6; --ink:#0f1519; --ink-2:#47535d;
  --muted:#8994a0; --faint:#aab3bc; --line:#e4e9ec; --hair:#eceff1; --border:rgba(15,21,25,.09);
  --brand:#0e8f96; --brand-ink:#0a6a70; --brand-2:#12a8a3; --brand-tint:rgba(14,143,150,.08);
  --c-weakened:#d03b3b; --c-improved:#2a6fd6; --c-nonbinder:#96a0aa; --amber:#c98a12;
  --shadow:0 1px 2px rgba(15,21,25,.04),0 8px 24px -6px rgba(15,21,25,.10);
}
:root[data-theme=dark]{ color-scheme:dark;
  --paper:#0a0e11; --surface:#141a1f; --surface-2:#10161a; --inset:#0e1418; --ink:#eef3f5; --ink-2:#aeb9c2;
  --muted:#7a8792; --faint:#5c6771; --line:#232c33; --hair:#1c242a; --border:rgba(255,255,255,.08);
  --brand:#2ec4c8; --brand-ink:#6bd8da; --brand-2:#39d0cf; --brand-tint:rgba(46,196,200,.11);
  --c-weakened:#e66b6b; --c-robust:#25b825; --c-improved:#4a90e8; --c-nonbinder:#8a95a0; --amber:#e0a531;
  --shadow:0 1px 2px rgba(0,0,0,.3),0 10px 30px -8px rgba(0,0,0,.5);
}
*{box-sizing:border-box}
html,body{height:100%}
body{margin:0;background:var(--paper);color:var(--ink);font-family:var(--sans);line-height:1.55;
  font-feature-settings:"cv05","ss01";-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility}
button{font:inherit;cursor:pointer}
::selection{background:color-mix(in srgb,var(--brand) 24%,transparent)}
:focus-visible{outline:2px solid var(--brand);outline-offset:2px}

/* ---------- app shell ---------- */
.app{display:grid;grid-template-columns:288px 1fr;height:100vh;overflow:hidden}
.sidebar{background:var(--surface-2);border-right:1px solid var(--border);display:flex;flex-direction:column;
  padding:20px 15px 15px;gap:18px;overflow:hidden}
.main{overflow-y:auto;position:relative}
.main::before{content:"";position:fixed;inset:0 0 auto 288px;height:340px;pointer-events:none;z-index:0;
  background:
    radial-gradient(120% 100% at 82% -10%, var(--brand-tint), transparent 55%),
    radial-gradient(circle at 1px 1px, var(--border) 1px, transparent 0) 0 0/22px 22px;
  -webkit-mask-image:linear-gradient(#000,transparent);mask-image:linear-gradient(#000,transparent);opacity:.5}
.mainwrap{position:relative;z-index:1;max-width:952px;margin:0 auto;padding:26px 34px 90px}

/* brand */
.brand{display:flex;align-items:center;gap:11px;padding:2px 4px}
.logo{width:38px;height:38px;border-radius:11px;display:grid;place-items:center;flex:none;color:#fff;
  background:linear-gradient(150deg,var(--brand-2),var(--brand-ink));box-shadow:0 4px 12px -3px var(--brand-tint),inset 0 1px 0 rgba(255,255,255,.2)}
.brand .nm{font-weight:700;font-size:17.5px;letter-spacing:-0.02em}
.brand .tg{font-size:11px;color:var(--muted);margin-top:-1px;letter-spacing:.01em}

.newbtn{display:flex;align-items:center;gap:8px;justify-content:center;width:100%;padding:10px;border-radius:11px;
  border:1px solid var(--border);background:var(--surface);color:var(--ink);font-weight:600;font-size:13.5px;
  box-shadow:var(--shadow-sm);transition:.14s}
.newbtn:hover{border-color:var(--brand);color:var(--brand-ink);box-shadow:var(--shadow)}
.newbtn svg{color:var(--brand)}
.methodbtn{display:flex;align-items:center;gap:8px;justify-content:center;width:100%;padding:8px;margin-top:-8px;
  border-radius:10px;border:none;background:transparent;color:var(--ink-2);font-weight:600;font-size:12.5px}
.methodbtn:hover{background:var(--brand-tint);color:var(--brand-ink)}
.methodbtn svg{color:var(--brand)}

/* methodology view */
.method{padding:30px 0 20px;max-width:772px}
.mh1{font-family:var(--serif);font-size:28px;font-weight:600;letter-spacing:-0.015em;margin:14px 0 12px;line-height:1.2}
.mlede{font-size:16px;color:var(--ink-2);line-height:1.62;margin:0 0 24px;max-width:66ch}
.mflow{display:flex;flex-wrap:wrap;align-items:center;gap:7px;padding:15px 16px;background:var(--surface);
  border:1px solid var(--border);border-radius:14px;box-shadow:var(--shadow-sm);margin-bottom:30px}
.mstep{font-size:12px;font-weight:600;padding:7px 12px;border-radius:9px;background:var(--brand-tint);color:var(--brand-ink);white-space:nowrap}
.marr{color:var(--faint);font-size:15px;font-weight:700}
.msec{margin-bottom:23px}
.msec h3{font-size:16px;font-weight:650;letter-spacing:-0.01em;margin:0 0 7px;display:flex;align-items:center;gap:12px}
.msec .mn{flex:none;width:27px;height:27px;border-radius:8px;background:var(--brand);color:#fff;display:grid;
  place-items:center;font-size:13px;font-weight:750;font-variant-numeric:tabular-nums}
.msec p,.msec ul{font-size:14px;line-height:1.65;color:var(--ink-2);margin:0 0 0 39px;max-width:74ch}
.msec ul{padding-left:18px} .msec li{margin:5px 0}
.msec code{background:var(--inset);padding:1px 5px;border-radius:4px;font-size:12.5px;font-family:var(--mono);color:var(--ink)}
.msec.valid .mn{background:var(--c-robust)} .msec.limits .mn{background:var(--amber)}
.msec b.mk-w{color:var(--c-weakened)} .msec b.mk-r{color:var(--c-robust)} .msec b.mk-i{color:var(--c-improved)} .msec b.mk-n{color:var(--muted)}

/* why-it-matters view */
.method.why .mh1{max-width:20ch}
.wsec{margin-bottom:24px}
.wsec h3{font-size:16.5px;font-weight:650;letter-spacing:-0.01em;margin:0 0 8px;color:var(--ink);
  display:flex;align-items:center;gap:10px}
.wsec h3::before{content:"";width:16px;height:2px;border-radius:2px;background:var(--brand);flex:none}
.wsec>p{font-size:14.5px;line-height:1.68;color:var(--ink-2);margin:0;max-width:78ch}
.pillars{display:grid;grid-template-columns:repeat(3,1fr);gap:13px;margin-top:2px}
.pillar{background:var(--surface);border:1px solid var(--border);border-radius:12px;padding:15px 16px;box-shadow:var(--shadow-sm)}
.pillar .pl-h{font-size:10.5px;font-weight:700;text-transform:uppercase;letter-spacing:.06em;color:var(--brand-ink);margin-bottom:8px}
.pillar p{font-size:13px;line-height:1.55;color:var(--ink-2);margin:0}
.wnote{background:var(--surface-2);border:1px solid var(--border);border-left:3px solid var(--brand);border-radius:12px;
  padding:16px 18px;font-size:14.5px;line-height:1.66;color:var(--ink-2);max-width:80ch}

.side-scroll{flex:1;overflow-y:auto;display:flex;flex-direction:column;gap:18px;margin:0 -5px;padding:0 5px}
.side-scroll::-webkit-scrollbar{width:8px}
.side-scroll::-webkit-scrollbar-thumb{background:var(--line);border-radius:4px}
.side-h{font-size:10px;font-weight:700;letter-spacing:.11em;text-transform:uppercase;color:var(--muted);margin:0 2px 9px;
  display:flex;align-items:center;gap:7px}
.side-h::after{content:"";flex:1;height:1px;background:var(--hair)}
.chips{display:flex;flex-direction:column;gap:6px}
.chip{display:flex;flex-direction:column;gap:2px;text-align:left;width:100%;padding:9px 12px;border-radius:11px;
  border:1px solid var(--border);background:var(--surface);color:var(--ink);position:relative;overflow:hidden;
  box-shadow:var(--shadow-sm);transition:border-color .14s,transform .05s,box-shadow .14s}
.chip::before{content:"";position:absolute;left:0;top:0;bottom:0;width:3px;background:var(--brand);opacity:0;transition:.14s}
.chip:hover{border-color:color-mix(in srgb,var(--brand) 45%,var(--border));box-shadow:var(--shadow)}
.chip:hover::before{opacity:.8}
.chip:active{transform:translateY(1px)}
.chip.active{border-color:var(--brand)}
.chip.active::before{opacity:1}
.chip .t{font-weight:650;font-size:13px;letter-spacing:-0.01em}
.chip .s{font-size:11px;color:var(--muted)}
.chip.gene .t{font-family:var(--mono);font-size:12.5px;letter-spacing:0}

.side-foot{border-top:1px solid var(--border);padding-top:13px;display:flex;flex-direction:column;gap:11px}
.usage{display:flex;align-items:center;gap:8px;font-size:11.5px;color:var(--ink-2)}
.usage svg{color:var(--muted);flex:none}
.usage #usageText{white-space:nowrap}
.usage .bar{flex:1;height:5px;border-radius:3px;background:var(--inset);overflow:hidden;border:1px solid var(--hair)}
.usage .bar i{display:block;height:100%;background:linear-gradient(90deg,var(--brand),var(--brand-2));border-radius:3px;transition:width .3s}
.foot-links{display:flex;align-items:center;gap:14px;font-size:11.5px}
.foot-links a{color:var(--muted);text-decoration:none}
.foot-links a:hover{color:var(--brand-ink)}
.themebtn{background:none;border:none;color:var(--muted);padding:2px;margin-left:auto;display:grid;place-items:center}
.themebtn:hover{color:var(--brand-ink)}

/* ---------- ask bar ---------- */
.ask{display:flex;gap:11px;align-items:stretch;margin-bottom:8px}
.ask .field{flex:1;position:relative;display:flex;align-items:center}
.ask .ask-ic{position:absolute;left:16px;color:var(--faint);pointer-events:none;z-index:1}
.ask input{width:100%;font-size:15.5px;padding:14px 16px 14px 44px;border-radius:14px;border:1px solid var(--border);
  background:var(--surface);color:var(--ink);box-shadow:var(--shadow);transition:.16s}
.ask input::placeholder{color:var(--faint)}
.ask input:focus{outline:none;border-color:var(--brand);box-shadow:var(--shadow),0 0 0 4px var(--brand-tint)}
.ask button.go{padding:0 22px;border-radius:14px;border:none;background:linear-gradient(160deg,var(--brand-2),var(--brand-ink));
  color:#fff;font-weight:650;font-size:14.5px;box-shadow:var(--shadow);transition:.14s;letter-spacing:.01em}
.ask button.go:hover{filter:brightness(1.06)}
.ask button.go:active{transform:translateY(1px)}
.ask button.go:disabled{opacity:.5;cursor:default}
.suggest{position:absolute;top:calc(100% + 7px);left:0;right:0;background:var(--surface);border:1px solid var(--border);
  border-radius:13px;box-shadow:var(--shadow-lg);overflow:hidden;z-index:20;padding:5px}
.suggest button{display:block;width:100%;text-align:left;padding:9px 13px;background:none;border:none;color:var(--ink);
  font-size:14px;border-radius:9px;font-family:var(--mono);font-size:13px}
.suggest button.new{font-family:var(--sans);font-size:13.5px;color:var(--ink-2)}
.suggest button:hover,.suggest button.hi{background:var(--brand-tint);color:var(--brand-ink)}
.hint{font-size:12.5px;color:var(--muted);margin:0 4px 0;transition:color .2s}

/* ---------- hero (split: value prop + live preview) ---------- */
.hero{padding:30px 0 8px}
.eyebrow{display:inline-flex;align-items:center;gap:7px;font-size:11px;font-weight:700;letter-spacing:.08em;
  text-transform:uppercase;color:var(--brand-ink);background:var(--brand-tint);padding:5px 11px;border-radius:20px;margin-bottom:18px}
.eyebrow::before{content:"";width:6px;height:6px;border-radius:50%;background:var(--brand);box-shadow:0 0 0 3px var(--brand-tint)}
.hero-split{display:grid;grid-template-columns:1.02fr 0.98fr;gap:46px;align-items:center;min-height:400px}
.hero-left h1{font-family:var(--serif);font-weight:600;font-size:39px;line-height:1.08;letter-spacing:-0.022em;
  margin:14px 0 16px;max-width:15ch;color:var(--ink)}
.hero-left .lede{font-size:16px;line-height:1.6;color:var(--ink-2);max-width:47ch;margin:0 0 26px}
.hero-cta .cta-label{font-size:11px;font-weight:700;letter-spacing:.08em;text-transform:uppercase;color:var(--muted);margin-bottom:11px}
.cta-chips{display:flex;flex-direction:column;gap:8px;max-width:400px}
.ctachip{display:flex;align-items:center;gap:11px;width:100%;text-align:left;padding:13px 15px;border-radius:12px;
  border:1px solid var(--border);background:var(--surface);color:var(--ink);box-shadow:var(--shadow-sm);transition:.16s}
.ctachip:hover{border-color:var(--brand);box-shadow:var(--shadow);transform:translateY(-1px)}
.ctachip .cc-t{font-family:var(--mono);font-weight:600;font-size:13.5px;letter-spacing:-0.02em}
.ctachip .cc-s{font-size:11.5px;color:var(--muted);margin-left:auto}
.ctachip .cc-arr{color:var(--brand);font-size:19px;font-weight:700;line-height:1;transition:transform .16s}
.ctachip:hover .cc-arr{transform:translateX(3px)}

/* the product-shot preview */
.hero-right{position:relative}
/* live 3D structure showpiece (sits above the result preview) */
.hero-mol{position:relative;z-index:1;border-radius:16px;overflow:hidden;cursor:pointer;margin-bottom:16px;
  border:1px solid var(--border);background:#0a0f14;
  box-shadow:0 1px 2px rgba(15,21,25,.05),0 30px 60px -26px rgba(15,21,25,.34);transition:transform .2s ease,box-shadow .2s ease}
.hero-mol:hover{transform:translateY(-3px);box-shadow:0 1px 2px rgba(15,21,25,.05),0 42px 78px -22px rgba(15,21,25,.42)}
.hm-stage{position:relative;height:196px;background:radial-gradient(120% 120% at 50% 28%,#132430,#0a0f14)}
.hm-stage iframe{position:absolute;inset:0;width:100%;height:100%;border:0;pointer-events:none;display:block}
.hm-badge{position:absolute;top:11px;left:12px;z-index:2;font-size:9px;font-weight:700;letter-spacing:.08em;
  text-transform:uppercase;color:#5eead4;background:rgba(45,212,191,.12);border:1px solid rgba(94,234,212,.28);
  padding:3px 8px;border-radius:20px}
.hm-x{position:absolute;bottom:11px;right:12px;z-index:2;font-size:11.5px;font-weight:600;color:#5eead4;opacity:.85;transition:.16s}
.hero-mol:hover .hm-x{opacity:1;transform:translateX(2px)}
.hm-cap{display:flex;flex-direction:column;gap:1px;padding:10px 14px;border-top:1px solid rgba(255,255,255,.06);background:#0c1319}
.hm-gt{font-family:var(--mono);font-size:12.5px;font-weight:600;color:#dbe7ec}
.hm-sub{font-size:11px;color:#8aa2b2}
.hero-right::before{content:"";position:absolute;inset:-14% -4% -14% 8%;z-index:0;pointer-events:none;
  background:radial-gradient(58% 56% at 62% 42%,var(--brand-tint),transparent 72%);filter:blur(26px)}
.preview{position:relative;z-index:1;border-radius:16px;background:var(--surface);cursor:pointer;overflow:hidden;
  border:1px solid var(--border);box-shadow:0 1px 2px rgba(15,21,25,.05),0 34px 64px -24px rgba(15,21,25,.30);
  transition:transform .2s ease,box-shadow .2s ease}
.preview:hover{transform:translateY(-3px);box-shadow:0 1px 2px rgba(15,21,25,.05),0 44px 82px -22px rgba(15,21,25,.36)}
.pv-top{display:flex;align-items:center;gap:9px;padding:10px 14px;border-bottom:1px solid var(--hair);background:var(--surface-2)}
.pv-dots{display:flex;gap:6px} .pv-dots i{width:8px;height:8px;border-radius:50%;background:var(--line)}
.pv-t{font-size:11.5px;font-weight:650;color:var(--ink-2)}
.pv-live{margin-left:auto;font-size:9px;font-weight:700;text-transform:uppercase;letter-spacing:.06em;color:var(--brand-ink);
  background:var(--brand-tint);padding:3px 8px 3px 6px;border-radius:20px;display:inline-flex;align-items:center;gap:5px}
.pv-live::before{content:"";width:5px;height:5px;border-radius:50%;background:var(--brand);box-shadow:0 0 0 3px var(--brand-tint)}
.pv-body{padding:16px 17px}
.pv-head{display:flex;align-items:center;gap:9px;margin-bottom:13px}
.pv-gt{font-family:var(--serif);font-size:18px;font-weight:600;letter-spacing:-0.01em}
.pv-chip{font-size:9.5px;font-weight:700;text-transform:uppercase;letter-spacing:.04em;color:var(--c-weakened);
  border:1px solid color-mix(in srgb,var(--c-weakened) 34%,var(--border));border-radius:20px;padding:2px 8px}
.pv-tiles{display:grid;grid-template-columns:repeat(3,1fr);gap:8px;margin-bottom:14px}
.pv-tile{border:1px solid var(--border);border-radius:10px;padding:9px 11px;position:relative;overflow:hidden;background:var(--surface-2)}
.pv-tile::before{content:"";position:absolute;left:0;top:0;bottom:0;width:3px}
.pv-tile.w::before{background:var(--c-weakened)} .pv-tile.r::before{background:var(--c-robust)} .pv-tile.h::before{background:var(--brand)}
.pv-tile b{display:block;font-size:20px;font-weight:750;letter-spacing:-0.02em;line-height:1;font-variant-numeric:tabular-nums}
.pv-tile span{font-size:10px;color:var(--ink-2);text-transform:uppercase;letter-spacing:.04em;font-weight:600}
.pv-rows{display:flex;flex-direction:column;gap:3px;margin-bottom:13px}
.pv-row{display:flex;align-items:center;gap:10px}
.pv-d{font-family:var(--mono);font-size:11.5px;width:72px;color:var(--ink)}
.pv-track{position:relative;flex:1;height:16px}
.pv-zero{position:absolute;left:50%;top:2px;bottom:2px;width:1px;background:var(--ink-2);opacity:.2}
.pv-dot{position:absolute;top:4px;width:9px;height:9px;border-radius:50%;margin-left:-4.5px;border:2px solid var(--surface);box-shadow:0 1px 2px rgba(0,0,0,.16)}
.pv-n{font-family:var(--mono);font-size:11.5px;font-weight:600;width:42px;text-align:right}
.pv-claude{display:flex;gap:9px;align-items:flex-start;font-size:12px;line-height:1.45;color:var(--ink-2);
  background:linear-gradient(var(--brand-tint),transparent);border:1px solid var(--border);border-radius:10px;padding:10px 12px}
.pv-cd{flex:none;color:var(--brand-ink);margin-top:1px} .pv-cd svg{width:15px;height:15px;display:block}
.pv-claude b{color:var(--brand-ink);font-weight:700}
.pv-hint{text-align:center;font-size:11.5px;color:var(--muted);margin-top:13px}

/* feature strip */
.featurestrip{display:grid;grid-template-columns:repeat(3,1fr);gap:18px;margin-top:40px;padding-top:26px;border-top:1px solid var(--hair)}
.fs{display:flex;gap:12px;align-items:flex-start}
.fs-ic{flex:none;width:34px;height:34px;border-radius:10px;background:var(--brand-tint);color:var(--brand-ink);display:grid;place-items:center}
.fs-ic svg{width:17px;height:17px}
.fs b{display:block;font-size:13px;margin-bottom:2px;letter-spacing:-0.01em}
.fs span{font-size:12px;line-height:1.5;color:var(--ink-2)}

/* ---------- run / pipeline ---------- */
.run{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius);padding:24px 26px;
  box-shadow:var(--shadow);margin-top:22px}
.run .rt{display:flex;align-items:center;gap:11px;margin-bottom:3px}
.run .rt b{font-size:17px;letter-spacing:-0.01em}
.run .rsub{font-size:13px;color:var(--ink-2);margin-bottom:22px}
.pipeline{display:flex;flex-direction:column;gap:1px}
.pstage{display:flex;align-items:center;gap:14px;padding:8px 0;position:relative}
.pstage .pd{width:24px;height:24px;border-radius:50%;flex:none;display:grid;place-items:center;
  border:2px solid var(--line);background:var(--surface);color:var(--faint);font-size:11.5px;font-weight:700;
  font-variant-numeric:tabular-nums;transition:.25s;z-index:1}
.pstage.running .pd{border-color:var(--brand);color:var(--brand);animation:pulse 1.3s ease-in-out infinite}
.pstage.done .pd{border-color:var(--brand);background:var(--brand);color:#fff}
.pstage .pn{font-size:14px;color:var(--faint);transition:.25s;letter-spacing:-0.005em}
.pstage.running .pn{color:var(--ink);font-weight:600}
.pstage.done .pn{color:var(--ink-2)}
.pstage:not(:last-child)::after{content:"";position:absolute;left:11px;top:30px;width:2px;height:12px;background:var(--line);transition:.25s}
.pstage.done:not(:last-child)::after{background:var(--brand)}
@keyframes pulse{0%,100%{box-shadow:0 0 0 0 var(--brand-tint)}50%{box-shadow:0 0 0 6px transparent}}

/* ---------- result ---------- */
.result{margin-top:20px;display:flex;flex-direction:column;gap:16px}
.rhead{display:flex;align-items:flex-start;gap:14px;flex-wrap:wrap;padding:4px 2px 0}
.rhead .gt{font-family:var(--serif);font-size:27px;font-weight:600;letter-spacing:-0.01em;line-height:1.2}
.rhead .gt .tgt{font-family:var(--sans);color:var(--muted);font-size:14px;font-weight:500}
.tags{display:flex;gap:7px;flex-wrap:wrap;margin-left:auto;padding-top:6px}
.tag{font-size:10px;font-weight:700;letter-spacing:.05em;text-transform:uppercase;padding:4px 10px;border-radius:20px;
  border:1px solid var(--border);color:var(--ink-2);background:var(--surface);white-space:nowrap}
.tag.cache{color:var(--brand-ink);border-color:color-mix(in srgb,var(--brand) 38%,var(--border));background:var(--brand-tint)}
.tag.modeled{color:var(--amber);border-color:color-mix(in srgb,var(--amber) 40%,var(--border));background:var(--amber-tint)}
.tag.computed{color:var(--c-robust);border-color:color-mix(in srgb,var(--c-robust) 40%,var(--border))}

.card{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius);box-shadow:var(--shadow-sm)}
.pad{padding:19px 22px}
.verdict-line{font-size:15.5px;line-height:1.6;color:var(--ink-2)}
.verdict-line b{color:var(--ink);font-weight:650}
.tiles{display:grid;grid-template-columns:repeat(3,1fr);gap:13px;margin-top:16px}
.tile{border:1px solid var(--border);border-radius:13px;padding:14px 16px;background:var(--surface-2);
  display:block;width:100%;text-align:left;font:inherit;cursor:pointer;position:relative;
  transition:border-color .14s,transform .06s,box-shadow .14s}
.tile:hover{box-shadow:var(--shadow)}
.tile:active{transform:translateY(1px)}
.tile.w{background:linear-gradient(var(--tint-w),var(--tint-w)),var(--surface);border-color:color-mix(in srgb,var(--c-weakened) 24%,var(--border))}
.tile.r{background:linear-gradient(var(--tint-r),var(--tint-r)),var(--surface);border-color:color-mix(in srgb,var(--c-robust) 24%,var(--border))}
.tile.h{background:linear-gradient(var(--brand-tint),var(--brand-tint)),var(--surface);border:2px solid color-mix(in srgb,var(--brand) 55%,var(--border));padding:13px 15px}
.tile.w:hover{border-color:color-mix(in srgb,var(--c-weakened) 50%,var(--border))}
.tile.r:hover{border-color:color-mix(in srgb,var(--c-robust) 50%,var(--border))}
.tile.h:hover{border-color:var(--brand)}
.tile .th{display:flex;align-items:center;gap:8px;margin-bottom:11px}
.tile .tic{flex:none;width:27px;height:27px;border-radius:8px;display:grid;place-items:center;background:var(--surface);border:1px solid var(--border)}
.tile .tic svg{width:16px;height:16px}
.tile.w .tic{color:var(--c-weakened)} .tile.r .tic{color:var(--c-robust)} .tile.h .tic{color:var(--brand-ink)}
.tile .k{font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.06em}
.tile.w .k{color:var(--c-weakened)} .tile.r .k{color:var(--c-robust)} .tile.h .k{color:var(--brand-ink)}
.tile .hbadge{margin-left:auto;display:inline-flex;align-items:center;gap:4px;font-size:10px;font-weight:700;
  letter-spacing:.03em;color:var(--brand-ink);background:var(--surface);border:1px solid color-mix(in srgb,var(--brand) 40%,var(--border));
  border-radius:20px;padding:3px 8px 3px 6px}
.tile .hbadge svg{width:11px;height:11px}
.tile .tn{display:flex;align-items:baseline;gap:6px}
.tile .n{font-size:31px;font-weight:700;letter-spacing:-0.03em;line-height:1;font-variant-numeric:tabular-nums;color:var(--ink)}
.tile .unit{font-size:12px;color:var(--ink-2)}
.tile .tsub{font-size:12px;color:var(--ink-2);margin:3px 0 11px;line-height:1.4}
.tile .tchips{display:flex;flex-wrap:wrap;gap:5px}
.tile .tchip{font-size:11px;padding:2px 8px;border-radius:20px;border:1px solid var(--border);
  background:var(--surface);color:var(--ink-2);white-space:nowrap}
.tile .tchip.more{border:none;background:none;color:var(--muted);padding:2px 2px}
.tile .tchip-none{font-size:12px;color:var(--muted)}

/* badges */
.badge{display:flex;gap:12px;align-items:flex-start;padding:14px 17px;font-size:13.5px;line-height:1.55}
.badge+.badge{border-top:1px solid var(--hair)}
.badge .ic{flex:none;width:23px;height:23px;border-radius:7px;display:grid;place-items:center;font-size:13px;font-weight:800;color:#fff;margin-top:1px}
.badge.valid .ic{background:var(--c-robust)} .badge.real .ic{background:var(--brand)} .badge.caveat .ic{background:var(--amber)}
.badge.valid{background:linear-gradient(var(--tint-r),var(--tint-r)),transparent}
.badge.real{background:var(--brand-tint)}
.badge.caveat{background:var(--amber-tint)}
.badge b{color:var(--ink);font-weight:650} .badge .bt{color:var(--ink-2)}

/* claude */
.claude{background:linear-gradient(var(--brand-tint),transparent 40%),var(--surface)}
.claude .ch{display:flex;align-items:center;gap:10px;padding:14px 20px;border-bottom:1px solid var(--hair)}
.claude .ch .dot2{width:20px;height:20px;border-radius:6px;background:linear-gradient(150deg,var(--brand-2),var(--brand-ink));
  flex:none;position:relative}
.claude .ch .dot2::after{content:"";position:absolute;inset:6px;border-radius:50%;background:#fff;opacity:.9}
.claude .ch b{font-size:14.5px;letter-spacing:-0.01em}
.claude .ch .mtag{margin-left:auto;font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.05em;
  color:var(--muted);border:1px solid var(--border);border-radius:20px;padding:3px 9px}
.claude .body{padding:10px 24px 20px;font-size:14.5px;line-height:1.68;color:var(--ink-2);max-width:74ch}
.claude .body h4{color:var(--brand-ink);font-size:14.5px;font-weight:650;letter-spacing:-0.01em;margin:19px 0 6px}
.claude .body h4:first-child{margin-top:2px}
.claude .body strong{color:var(--ink);font-weight:650}
.claude .body ul{margin:6px 0;padding-left:19px}
.claude .body li{margin:3px 0}
.claude .body p{margin:8px 0}

/* evidence disclosure */
.disclose>summary{list-style:none;cursor:pointer;padding:15px 20px;display:flex;align-items:center;gap:10px;
  font-weight:650;font-size:14.5px;letter-spacing:-0.01em;user-select:none}
.disclose>summary::-webkit-details-marker{display:none}
.disclose>summary .chev{margin-left:auto;color:var(--muted);transition:transform .2s}
.disclose[open]>summary{border-bottom:1px solid var(--hair)}
.disclose[open]>summary .chev{transform:rotate(90deg)}
.disclose>summary .sh{font-weight:400;color:var(--muted);font-size:12.5px}
.evidence{padding:14px 20px 16px}
.legend{display:flex;flex-wrap:wrap;align-items:center;gap:14px;font-size:12px;color:var(--ink-2);padding:2px 2px 12px}
.legend .it{display:flex;align-items:center;gap:6px}
.sw{width:10px;height:10px;border-radius:3px;display:inline-block}
.sw.sw-band{background:var(--inset);border-left:1px dashed var(--faint);border-right:1px dashed var(--faint);border-radius:0}
.ev-axis{margin-left:auto;color:var(--muted);font-size:11.5px;font-variant-numeric:tabular-nums}
.bucket{border:1px solid var(--border);border-radius:13px;padding:2px 15px 9px;margin-bottom:11px;border-left-width:3px;border-left-style:solid}
.bucket.b-weakened{border-left-color:var(--c-weakened);background:linear-gradient(var(--tint-w),var(--tint-w)),var(--surface)}
.bucket.b-robust{border-left-color:var(--c-robust);background:linear-gradient(var(--tint-r),var(--tint-r)),var(--surface)}
.bucket.b-improved{border-left-color:var(--c-improved);background:linear-gradient(var(--tint-i),var(--tint-i)),var(--surface)}
.bucket.b-non-binder{border-left-color:var(--c-nonbinder);background:linear-gradient(var(--tint-n),var(--tint-n)),var(--surface)}
.bhead{display:flex;align-items:center;gap:9px;font-size:14px;font-weight:700;padding:12px 0 6px;letter-spacing:-0.01em}
.bhead .desc{font-weight:400;color:var(--ink-2);font-size:12.5px}
.bhead .ct{margin-left:auto;color:var(--muted);font-size:11.5px;font-weight:600;font-variant-numeric:tabular-nums}
table.rows{width:100%;border-collapse:collapse}
.rows td{padding:0 6px;border-top:1px solid var(--hair);vertical-align:middle}
.rows tr:first-child td{border-top:none}
.rows tr:hover td{background:var(--brand-tint)}
.bucket.flash{animation:bflash 1.2s ease-out}
@keyframes bflash{0%,100%{box-shadow:none}22%{box-shadow:0 0 0 3px color-mix(in srgb,var(--brand) 34%,transparent)}}
.dname{font-weight:600;font-size:13.5px;white-space:nowrap;font-family:var(--mono);letter-spacing:-0.02em}
.bench{display:inline-block;font-family:var(--sans);font-size:9px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;
  color:var(--brand-ink);border:1px solid color-mix(in srgb,var(--brand) 40%,var(--border));border-radius:5px;padding:0 4px;margin-left:7px;vertical-align:1px}
.cat{display:block;color:var(--muted);font-size:10.5px;font-weight:400;margin-top:2px;font-family:var(--sans)}
.track{position:relative;height:38px;min-width:170px}
.band{position:absolute;top:0;bottom:0;background:var(--inset);border-left:1px dashed var(--faint);border-right:1px dashed var(--faint)}
.zero{position:absolute;top:0;bottom:0;width:1.5px;margin-left:-.75px;background:var(--ink-2);opacity:.26}
.ci{position:absolute;top:50%;height:5px;border-radius:3px;opacity:.32;transform:translateY(-50%)}
.dot{position:absolute;top:50%;width:10px;height:10px;border-radius:50%;margin-left:-5px;transform:translateY(-50%);
  border:2px solid var(--surface);box-shadow:0 1px 2px rgba(15,21,25,.2);z-index:2}
.chev-o{position:absolute;top:50%;transform:translateY(-50%);font-size:16px;line-height:1;font-weight:800;z-index:2}
.num{font-variant-numeric:tabular-nums;text-align:right;white-space:nowrap;font-size:13px;font-weight:600;font-family:var(--mono)}
.ci-txt{font-variant-numeric:tabular-nums;color:var(--muted);font-size:11.5px;white-space:nowrap;font-family:var(--mono)}
.conf-cell{width:64px;text-align:right;white-space:nowrap}
.conf-ok{display:inline-block;width:7px;height:7px;border-radius:50%;background:var(--faint)}
.conf-flag{display:inline-flex;align-items:center;gap:3px;font-size:9.5px;font-weight:700;text-transform:uppercase;
  letter-spacing:.04em;color:var(--amber);background:var(--amber-tint);border-radius:20px;padding:2px 7px 2px 5px}
.conf-flag svg{width:11px;height:11px}
.conf-flag.low{color:var(--c-weakened);background:color-mix(in srgb,var(--c-weakened) 12%,transparent)}
.foot-note{font-size:11.5px;line-height:1.6;color:var(--muted);padding:2px 4px;max-width:92ch}

/* ---------- orthogonal evidence axes (pathway grounding + DepMap dependency) ---------- */
/* two quiet stacked micro-pills per drug row, on a shared teal->amber->grey "belief" ramp:
   does the biology corroborate the docking score? triple-encoded (color + dot shape + word). */
.oe-cell{width:104px;padding:2px 8px 2px 2px;vertical-align:middle}
.oe{display:inline-flex;align-items:center;gap:4px;width:100%;white-space:nowrap;
  font-size:9.5px;font-weight:700;letter-spacing:.01em;line-height:1.4;
  padding:1px 7px 1px 5px;border-radius:20px;border:1px solid var(--border);color:var(--muted)}
.oe+.oe{margin-top:3px}
.oe-dot{flex:none;width:7px;height:7px;border-radius:50%;border:1.5px solid currentColor;background:transparent}
.oe.lvl-hi{color:var(--brand-ink);background:var(--brand-tint);border-color:color-mix(in srgb,var(--brand) 32%,var(--border))}
.oe.lvl-hi .oe-dot{background:currentColor}
.oe.lvl-mid{color:var(--amber);background:var(--amber-tint);border-color:color-mix(in srgb,var(--amber) 34%,var(--border))}
.oe.lvl-mid .oe-dot{background:linear-gradient(90deg,currentColor 50%,transparent 50%)}
.oe.lvl-lo{color:var(--muted);background:transparent;border-color:var(--border)}
.oe.lvl-lo .oe-dot{background:transparent}
.legend .leg-sep{width:1px;height:12px;background:var(--line);margin:0 2px}
.legend .oe-dot{border:1.5px solid currentColor}

/* the "Orthogonal evidence" leads strip (echoes the .claude header + .badge rows) */
.oe-strip{overflow:hidden}
.oe-strip-h{display:flex;align-items:baseline;gap:9px;flex-wrap:wrap;padding:12px 18px;
  border-bottom:1px solid var(--hair);background:linear-gradient(var(--brand-tint),transparent)}
.oe-strip-t{font-size:13px;font-weight:700;letter-spacing:-0.01em;color:var(--brand-ink)}
.oe-strip-s{font-size:11.5px;color:var(--muted)}
.oe-lead{display:flex;align-items:center;gap:9px;flex-wrap:wrap;padding:11px 18px}
.oe-lead+.oe-lead{border-top:1px solid var(--hair)}
.oe-lead-d{font-family:var(--mono);font-size:12.5px;font-weight:600;letter-spacing:-0.02em;width:92px;color:var(--ink)}
.oe-lead .oe{width:auto}
.oe-lead-note{flex:1;min-width:220px;font-size:12px;line-height:1.45;color:var(--ink-2)}
@media (max-width:860px){ .oe-cell{display:none} }

/* ---------- result chat (grounded conversation about this result) ---------- */
.chat{display:flex;flex-direction:column;background:linear-gradient(var(--brand-tint),transparent 40%),var(--surface)}
.chat .ch{display:flex;align-items:center;gap:10px;padding:14px 20px;border-bottom:1px solid var(--hair)}
.chat .ch .dot2{width:20px;height:20px;border-radius:6px;background:linear-gradient(150deg,var(--brand-2),var(--brand-ink));flex:none;position:relative}
.chat .ch .dot2::after{content:"";position:absolute;inset:6px;border-radius:50%;background:#fff;opacity:.9}
.chat .ch b{font-size:14.5px;letter-spacing:-0.01em}
.chat .ch .mtag{margin-left:auto;font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.05em;
  color:var(--muted);border:1px solid var(--border);border-radius:20px;padding:3px 9px}
.chat-scroll{max-height:430px;overflow-y:auto;padding:16px 20px;display:flex;flex-direction:column;gap:12px}
.chat-scroll::-webkit-scrollbar{width:8px}
.chat-scroll::-webkit-scrollbar-thumb{background:var(--line);border-radius:4px}
.chat-empty p{font-size:13.5px;line-height:1.55;color:var(--ink-2);margin:2px 0 12px;max-width:64ch}
.chat-suggs{display:flex;flex-direction:column;gap:7px;align-items:flex-start}
.chat-sugg{font-size:12.5px;text-align:left;color:var(--brand-ink);background:var(--brand-tint);line-height:1.35;
  border:1px solid color-mix(in srgb,var(--brand) 26%,var(--border));border-radius:20px;padding:7px 13px;transition:.14s}
.chat-sugg:hover{border-color:var(--brand);background:color-mix(in srgb,var(--brand) 12%,transparent)}
.cm{display:flex;gap:9px;align-items:flex-start;max-width:100%}
.cm.user{justify-content:flex-end}
.cm .cm-b{font-size:14px;line-height:1.6;border-radius:13px;padding:10px 14px;max-width:82%}
.cm.user .cm-b{background:var(--brand);color:#fff;border-bottom-right-radius:4px}
.cm.bot .cm-b{background:var(--surface-2);border:1px solid var(--border);color:var(--ink-2);border-bottom-left-radius:4px}
.cm.bot .cm-b p{margin:6px 0} .cm.bot .cm-b p:first-child{margin-top:0} .cm.bot .cm-b p:last-child{margin-bottom:0}
.cm.bot .cm-b strong{color:var(--ink);font-weight:650}
.cm.bot .cm-b ul{margin:6px 0;padding-left:18px} .cm.bot .cm-b li{margin:2px 0}
.cm.bot .cm-b h4{color:var(--brand-ink);font-size:14px;font-weight:650;margin:10px 0 4px}
.cm-ic{flex:none;width:26px;height:26px;border-radius:8px;display:grid;place-items:center;background:var(--brand-tint);color:var(--brand-ink);margin-top:1px}
.cm-ic svg{width:15px;height:15px}
.cm-ic.err{background:var(--amber-tint);color:var(--amber)}
.cm-b.cm-err{background:var(--amber-tint);border-color:color-mix(in srgb,var(--amber) 30%,var(--border));color:var(--ink-2)}
.cm-typing{display:inline-flex;gap:4px;padding:3px 0}
.cm-typing i{width:6px;height:6px;border-radius:50%;background:var(--faint);animation:ctyp 1.1s infinite ease-in-out}
.cm-typing i:nth-child(2){animation-delay:.15s} .cm-typing i:nth-child(3){animation-delay:.3s}
@keyframes ctyp{0%,60%,100%{opacity:.3;transform:translateY(0)}30%{opacity:1;transform:translateY(-3px)}}
.chat-inrow{display:flex;gap:9px;align-items:center;padding:12px 16px;border-top:1px solid var(--hair)}
.chat-inrow input{flex:1;font-size:14px;padding:11px 14px;border-radius:12px;border:1px solid var(--border);
  background:var(--surface);color:var(--ink);transition:.15s}
.chat-inrow input::placeholder{color:var(--faint)}
.chat-inrow input:focus{outline:none;border-color:var(--brand);box-shadow:0 0 0 3px var(--brand-tint)}
.chat-send{flex:none;width:40px;height:40px;border-radius:12px;border:none;color:#fff;display:grid;place-items:center;
  background:linear-gradient(160deg,var(--brand-2),var(--brand-ink));transition:.14s}
.chat-send:hover{filter:brightness(1.06)} .chat-send:active{transform:translateY(1px)}
.chat-send svg{width:17px;height:17px}
.chat-foot{font-size:11px;color:var(--muted);padding:0 20px 14px;line-height:1.5}

/* notices */
.notice{border:1px solid var(--border);border-radius:var(--radius);padding:20px 22px;background:var(--surface);box-shadow:var(--shadow-sm);margin-top:20px}
.notice.gpu{border-left:3px solid var(--brand)}
.notice.err{border-left:3px solid var(--c-weakened);background:linear-gradient(var(--tint-w),transparent 30%),var(--surface)}
.notice h3{margin:0 0 7px;font-size:16.5px;letter-spacing:-0.01em}
.notice p{margin:0 0 13px;color:var(--ink-2);font-size:14px;line-height:1.6}
.notice code{background:var(--inset);padding:2px 6px;border-radius:5px;font-size:12.5px;font-family:var(--mono);color:var(--ink)}
.notice .row{display:flex;gap:10px;flex-wrap:wrap;align-items:center}
.notice input{flex:1;min-width:150px;padding:10px 13px;border-radius:10px;border:1px solid var(--border);background:var(--surface-2);color:var(--ink);font-size:13px}
.notice input:focus{outline:none;border-color:var(--brand)}
.notice .connect{padding:10px 18px;border-radius:10px;border:none;background:linear-gradient(160deg,var(--brand-2),var(--brand-ink));color:#fff;font-weight:600}
.notice .connect:disabled{opacity:.6}
.secure{font-size:11.5px;color:var(--muted);margin-top:11px;line-height:1.5}

.tip{position:fixed;pointer-events:none;z-index:40;background:var(--ink);color:var(--paper);font-size:12px;padding:9px 11px;
  border-radius:9px;max-width:300px;opacity:0;transition:opacity .1s;box-shadow:var(--shadow-lg);line-height:1.45}
.tip b{color:#fff}

/* ---------- 3D structure viewer ---------- */
.rhead-right{display:flex;align-items:center;gap:10px;margin-left:auto;flex-wrap:wrap;padding-top:2px}
.rhead-right .tags{margin-left:0;padding-top:0}
.struct-btn{display:inline-flex;align-items:center;gap:7px;font-family:var(--sans);font-size:12.5px;font-weight:600;
  color:var(--brand-ink);background:var(--brand-tint);border:1px solid color-mix(in srgb,var(--brand) 32%,transparent);
  border-radius:9px;padding:7px 12px;cursor:pointer;transition:.15s;white-space:nowrap;line-height:1}
.struct-btn:hover{background:color-mix(in srgb,var(--brand) 15%,transparent);border-color:var(--brand)}
.struct-btn svg{width:14px;height:14px;flex:none}

.struct-modal{position:fixed;inset:0;z-index:60;display:none}
.struct-modal.open{display:block}
.sm-backdrop{position:absolute;inset:0;background:rgba(4,10,14,.72);backdrop-filter:blur(3px)}
.sm-panel{position:absolute;inset:3.5vh 3.5vw;background:#0a0f14;border:1px solid var(--border);border-radius:16px;
  overflow:hidden;box-shadow:var(--shadow-lg);display:flex;flex-direction:column}
.sm-bar{display:flex;align-items:center;gap:12px;padding:11px 15px;border-bottom:1px solid rgba(255,255,255,.07);
  background:rgba(10,15,20,.92);color:#e7eef3;flex:none}
.sm-title{font-weight:600;font-size:13px}
.sm-sub{font-family:var(--mono);font-size:12px;color:#5eead4}
.sm-close{margin-left:auto;background:transparent;border:1px solid rgba(255,255,255,.16);color:#cdd8de;
  width:30px;height:30px;border-radius:8px;cursor:pointer;font-size:13px;line-height:1;transition:.14s}
.sm-close:hover{background:rgba(255,255,255,.08);color:#fff}
.sm-frame{flex:1;width:100%;border:0;background:#0a0f14;display:block}
@media (max-width:860px){ .sm-panel{inset:0;border-radius:0} }

@media (max-width:860px){
  .app{grid-template-columns:1fr;height:auto}
  .sidebar{border-right:none;border-bottom:1px solid var(--border);height:auto}
  .main::before{inset:0;height:240px}
  .hero-split{grid-template-columns:1fr;gap:30px;min-height:0}
  .featurestrip,.tiles,.pillars{grid-template-columns:1fr}
  .ci-txt{display:none}
  .hero-left h1{font-size:30px}
}